Proteomics Platform

Knapp Center for Biomedical Discovery
900 E 57th Street
Room 4140
Chicago, IL 60637

The Proteomics Platform at the University of Chicago is a mass spectrometry-based proteomics research facility located in the Knapp Center for Biomedical Discovery (KCBD). This platform is directed by Dr. Raymond Moellering, a faculty director as well as managed the day-to-day operation by Shao Huan Samuel Weng, a platform director. The mission of the facility is to work in collaboration with groups from UChicago and external organizations or companies to develop and utilize top-notch proteomics techniques to answer both basic and translational scientific questions. The platform has state-of-the-art mass spectrometry instruments including Thermo Scientific Orbitrap Eclipse Tribrid Mass Spectrometer and Thermo Scientific Orbitrap Exploris 480 Quadrupole Mass Spectrometer coupled with UltiMate 3000 RSLCnano liquid chromatography system and FAIMS Pro Interface. The Proteomics Platform has the capabilities for various proteomics analysis such as global, targeted and quantitative proteomics, deep proteome analysis, post-translational modification analysis, thermal profiling analysis, immunopeptidomics, and clinical proteomics. The platform also supports scientific consultation tailored to each project, proteomics sample preparation, and education to help researchers design, perform, and interpret complex proteomics data.

The Proteomics Platform has partnered with the Center for Research Informatics (CRI) at the University of Chicago to maintain databases, raw data and analysis. The Proteomics Platform has collaborated with Dr. Ahmed Fadiel, a director in Computational Oncology Unit for advanced proteomics data analysis. The core may be identified in publications as The University of Chicago Proteomics Platform (RRID:SCR_022928).